Leslie Bibb as KATE - one of three long-time friends on a girls’ trip after not having seen each other for a while 

Carrie Coon as LAURIE - one of three long-time friends on a girls’ trip after not having seen each other for a while 

Walton Goggins as RICK HATCHETT – a rugged man with a chip on his shoulder, traveling with his girlfriend Chelsea 

Sarah Catherine Hook as PIPER RATLIFF – a college senior and middle child to Timothy and Victoria Ratliff, Piper is a religion studies major 

Jason Isaacs as TIMOTHY RATLIFF – a wealthy businessman vacationing with his wife and three children 

Lalisa Manobal as MOOK – one of the health mentors for guests staying at The White Lotus 

Michelle Monaghan as JACLYN – one of three long-time friends on a girls’ trip after not having seen each other for a while 

Sam Nivola as LOCHLAN RATLIFF – Timothy and Victoria Ratliff’s youngest, a high school senior  

Lek Patravadi as SRITALA – one of the owners of The White Lotus and the visionary behind its wellness program 

Parker Posey as VICTORIA RATLIFF – vacationing with her husband and three children 

Natasha Rothwell as BELINDA – spa manager from The White Lotus in Hawaii 

Patrick Schwarzenegger as SAXON RATLIFF – the eldest son of Timothy and Victoria Ratliff, Saxon works for his father’s successful company 

Tayme Thapthimthong as GAITOK – a security guard at The White Lotus 

Aimee Lou Wood as CHELSEA – a free-spirit, traveling with her on-edge older boyfriend Rick