Emily Watson as Mother Superior Valya Harkonnen 

• As the second Mother Superior of the Sisterhood, Valya Harkonnen works to grow the Order’s power in the young Imperium, while using her relentless will to defend it against a new enemy.    
   

Olivia Williams as Reverend Mother Tula Harkonnen 

• Reverend Mother Tula Harkonnen is used to living her life in the shadow of her older sister Valya, but when an outside force threatens the Sisterhood, she is called upon to lead. To do so, she must choose between the Order’s needs and her own.    
   

Jihae as Reverend Mother Kasha   

• As the Emperor’s own Truthsayer and confidant, Reverend Mother Kasha occupies a position of great influence in the Imperium. When she begins to question the Sisterhood’s intentions, she finds her role increasingly difficult to navigate.  
   

Tabu as Sister Francesca 

• Strong, intelligent, and alluring, Sister Francesca leaves a lasting impression in her wake. 
   

Jade Anouka as Sister Theodosia 

• A talented and ambitious acolyte who harbors a dangerous secret about her past, Sister Theodosia is deeply loyal to the Sisterhood, which once gave her sanctuary in a time of need.
   

Faoileann Cunningham as Sister Jen 

• A fiercely independent and unpredictable acolyte, Sister Jen questions where her loyalty lies as she learns more about the Sisterhood.
   

Aoife Hinds as Sister Emeline 

• A gifted, but zealous acolyte descended from a long line of martyrs, Sister Emeline seeks to bring a religious influence to the Sisterhood.  
   

Chloe Lea as Sister Lila 

• A young acolyte with a deep empathy beyond her years, Sister Lila was raised at the Sisterhood since her infancy and has no knowledge regarding her family of origin. Although she believes in the Sisterhood’s mission, she longs to know more about her roots.
   

Shalom Brune-Franklin as Mikaela 

• A Fremen woman on a foreign planet, Mikaela does what she needs to do to survive in the shadows.   
   

Travis Fimmel as Desmond Hart 

• A charismatic soldier with an enigmatic past who seeks to gain the Emperor’s trust.  
   

Mark Strong as Emperor Javicco Corrino 

• Descended from a great line of Emperors, Emperor Corrino is called upon to govern the Imperium and manage a fragile peace.  
   

Jodhi May as Empress Natalya Arat Corrino 

• A formidable royal who united thousands of worlds through her marriage to Emperor Javicco Corrino, Empress Natalya wishes to make her own contribution to the young Imperium.
   

Sarah-Sofie Boussnina as Princess Ynez Corrino 

• An independent young princess dealing with the pressures of being heir to the throne, Ynez plans to study with the Sisterhood.  
   

Josh Heuston as Constantine Corrino 

• The illegitimate son of Emperor Corrino, Constantine is torn between seeking his father’s approval and indulging his own vices.  
   

Chris Mason as Keiran Atreides 

• As royal swordmaster, Keiran Atreides struggles with the corruption of the court and the legacy of his family name.
   

Edward Davis as Harrow Harkonnen 

• A lowly, but cunning politician from a once-great family, Harrow Harkonnen harbors a strong desire to elevate his House to its former glory.  
   

Mark Addy as Evgeny Harkonnen 

• Uncle of Valya Harkonnen, Evgeny is the patriarch of the family and blames his niece for cementing his House’s lowly status.